What's the difference between a spike prepared for a Koloss and a spike prepared for a Mistwraith or Kandra? What side effects might occur from... [?]... Koloss spikes?
It's the pieces of the soul that are being ripped off and the amount of the soul that's being ripped off. That's a big part of it. What side effects would there be? You would probably not get something as intelligent.
What's the difference in how you prepare those spikes?
The Koloss spikes, you've seen how their done. The Kandra spikes were prepared by the Lord Ruler. He gave them to them, and so we don't know what he did, at least in canon.
That means that we kind of screwed up the role playing.
You can totally do- I imagine all the role playing happening in a slightly different alternate universe, where there are slight variations and differences.
But yeah, there are no- Kandra spikes are prepared and given by the Lord Ruler, they didn't even know how to make them themselves. I mean they had an inkling of what went on, but they didn't know.