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In the most recent Hero of Ages annotation, you said that Preservation chose Vin to be the recipient of the power, just as Preservation had chosen Alendi previously (thus, this was why Ruin had manipulated the Prophecies). Was Alendi also chosen precisely sixteen years before the Well of Ascension's power returned?
Yes. He was chosen exactly sixteen years before, but he was a bit older then Vin when he was chosen.
Also, as a note, Alendi was an Allomancer, as the epigraph notes here. He had to be—he heard the pulsing at the Well of Ascension when nobody else could. "Ah," you might say, "but I thought that you said Allomancy didn't exist before those beads." That isn't 100% true. The legends say that Allomancy came with the Deepness. Alendi was one of the very first Allomancers, and he gained his powers as the mists began to cover the world.
That's important. ;)
Because, of course, he was Snapped by the mists, like is happening to people in this book.
The Mists Chose Someone
There's a lot more going on behind the scenes than even the author of these epigraphs knows. Reasons why Vin was chosen, and why the power of Preservation needed a new mind to control it.
The author is right in that Preservation did need someone to control its power, and it did seek for a host in which to invest itself. It began this search with what mind it had left about sixteen years before the return of the power to the Well of Ascension, just as it began a search for a new host before the return of the power the previous time.
Unfortunately, just as Ruin took control and manipulated Alendi, he took control and manipulated Vin.